Te Whakamahinga e whitu nga Kaihoko Antithrombotic
E rua nga momo o te pūmua ki te pānga antithrombotic i roto i te nakahi weriweri, kotahi e taea ki te Ko te whākōkī hono ki fibrinolytic whākōkī i huaina fibrinolytic whākōkī (plasmine，FLE) 。 I tua atu ki te whakaiti fibrin me fibrinogen,Karekau he whakahohenga o te plasminogen i roto i te tinana o te tangata, kahore. hydrolysis o etahi atu take coagulation Me te membrane platelet, me te whai hua antithrombotic.Ko tetahi atu ma te pehi i te whakaritenga Prothrombin ka whakahohehia ki te whakaroa i te mahi whakamohoatanga, karekau he mahi enaa.
Ko tenei momo enzyme i hangaia tuatahi e Atoda et al A ka matapakihia te tikanga anticoagulation o te pūmua anticoagulant, Kua whakapumautia ko te paanga o te tauwehe coagulation IX ranei te tauwehe coagulation X i runga i te konupūmā katote Hanga 1:1 matatini ki te roa te wa coagulation;I muri mai, ko Lu et al.mai i Agkistrodon acutus i te tonga o Anhui He take anticoagulant ACFI i wehea mai i te nakahi.Liu Qing Liang et al.i kitea ko te ACFI kei roto i te katote konupūmā, I whakapumautia ano ko tana mahi anticoagulant me te hanganga mokowhiti e pa ana ki nga katote konupūmā. I kitea e te rangahau whakatinana tikanga he rite ki te AC FI, no te waahanga tuarua.Zhai Ning et al.i wehea he mea anticoagulant ne mai i te paihana o Agkistrodon acutus, me ona ahuatanga tinana me te matū i akohia, ka kitea kaore he mahi fibrinolytic me te mahi phospholipase A 2 me te mahi toto.I wehea e Qian Xiaojiang me etahi atu te paihana o Agkistrodon acutus mai i Hunan Ko te waahanga hohe fibrinolytic i wehea me te whakapumau i te whakamatautau thrombolytic in vitro Kua kitea te paanga thrombolytic.I wehea a Lei Danqing e toru nga tikanga chromatography Na ka tino pai ake te mahi o te plasmin.Na te mea kei roto i te waahanga plasmin Ko te waahanga toto he uaua ki te wehe, a kaore i te kitea tona uara tono haumanu.Li Zhaoyan et al Na roto i te ngana ki te whiwhi i te whanariki fibrinolytic me te kore e whakaheke toto nga waahanga Ka whakaratohia te tautoko hangarau e.I whakamatauhia e Zhou Xianli [18] na roto i nga whakamatautau ko te Thrombin rite te enzyme me te plasmin mai i te Agkistrodon halys venom he tino whai hua thrombolytic, engari Ko te hua tika o te plasmin he kaha ake i te thrombin rite enzyme, Na reira, ko te thrombin rite te enzyme he kaihoko thrombolytic puhoi, e hanga te reanalization o oko toto āta, Whakarei ake i te kātakí o nga oko toto i roto i te rohe ischemic, ka ora i te rupture vascular meinga e te toto perfusion he pai te pānga o Cleavage i runga i te tīmatanga o te thrombosis, a ka whakamahia tahi e rua, Ka taea e te whakaiti te inenga me te whakatutuki i nga hua anticoagulant me te thrombolytic. Te tono mo nga Kaipupuri Antithrombotic E whitu E rua nga momo o nga pūmua me te paanga antithrombotic i roto i te weriweri nakahi, ka taea e tetahi te Ko te enzyme e hono ana ki te fibrinolytic enzyme ka kiia ko te fibrinolytic enzyme (plasmine，FLE). whakakino te fibrin me te fibrinogen, Karekau he whakahohenga o te plasminogen i roto i te tinana o te tangata, karekau he hydrolysis o etahi atu mea whakakoi me te pereti pereti, me te maarama antithrombotic.Ko tetahi atu ma te pehi i te whakaritenga Prothrombin ka whakahohehia ki te whakaroa i te mahi whakamohoatanga, karekau he mahi enaa.
Ko tenei momo enzyme i hangaia tuatahi e Atoda et al A ka matapakihia te tikanga anticoagulation o te pūmua anticoagulant, Kua whakapumautia ko te paanga o te tauwehe coagulation IX ranei te tauwehe coagulation X i runga i te konupūmā katote Hanga 1:1 matatini ki te roa te wa coagulation;I muri mai, ko Lu et al.mai i Agkistrodon acutus i te tonga o Anhui He take anticoagulant ACFI i wehea mai i te nakahi.Liu Qing Liang et al.i kitea kei roto i te ACF te konupūmā katote I whakapumautia ano ko tana mahi anticoagulant me te hanganga mokowhiti he hononga ki nga katote konupūmā.I muri mai, ka wehea e Xu Xiaolong me etahi atu te ware o te Agkistrodon acutus mai i te Agkistrodon acutus ma te whakapai ake i te tikanga wehewehe Ko tetahi atu take anticoagulant ACFI I I kitea e te rangahau whakatinanatanga he rite ki te AC FI, no te waahanga tuarua.Zhai Ning et al.i wehea he tauwehe anticoagulant hou mai i te paihana o Agkistrodon acutus, a I akohia ona ahuatanga tinana me te matū, a ka kitea kaore he mahi fibrinolytic me te mahi phospholipase A 2 me te mahi whakaheke toto.I wehea e Qian Xiaojiang me etahi atu te paihana o Agkistrodon acutus mai i Hunan Ko te waahanga hohe fibrinolytic i wehea me te whakapumau i te whakamatautau thrombolytic in vitro Kua kitea te paanga thrombolytic.I wehea a Lei Danqing e toru nga tikanga chromatography Na ka tino pai ake te mahi o te plasmin.Na te mea kei roto i te waahanga plasmin Ko te waahanga toto he uaua ki te wehe, a kaore i te kitea tona uara tono haumanu.Li Zhaoyan et al Na roto i te ngana ki te whiwhi i te whanariki fibrinolytic me te kore e whakaheke toto nga waahanga Ka whakaratohia te tautoko hangarau e.I whakamatauhia e Zhou Xianli [18] na roto i nga whakamatautau ko te Thrombin rite te enzyme me te plasmin mai i te Agkistrodon halys venom he tino whai hua thrombolytic, engari Ko te hua tika o te plasmin he kaha ake i te thrombin rite enzyme, Na reira, ko te thrombin rite te enzyme he kaihoko thrombolytic puhoi, e hanga te reanalization o oko toto āta, Whakarei ake i te kātakí o nga oko toto i roto i te rohe ischemic, a ka ora i te rupture vascular meinga e te toto perfusion he pai te pānga o Cleavage i runga i te tīmatanga o te thrombosis, a ka whakamahia tahi e rua.
Ka taea te whakaheke i te inenga me te whakatutuki i nga hua anticoagulant me te thrombolytic.
Wā tuku: Oketopa-19-2022